Peyronie’s Disease

Landon Trost, M.D., provides a general background of Peyronie’s disease. Topics include: common symptoms at presentation, how often the condition occurs, populations of men where this is more common, age of onset, average curvatures, typical directions of curvature, and associated psychological conditions.

Landon Trost, M.D., Assistant Professor of Urology and current Head of Andrology and Male Infertility, Mayo Clinic, Rochester, Minnesota discusses Peyronies Disease therapies. He defines the therapeutic objectives and how curvature is often a primary end-point of therapy.


— Up to 7 percent of men can experience an abnormal curvature of their penis when it is erect. This is known as Peyronie’s disease. The most common cause of Peyronie’s disease is penile trauma that occurs during sexual intercourse. The penis develops a scar, and this scar then causes the penis to bend when it is erect. Significant penile curvatures can result in pain, poor erections, and an inability to engage in sexual intercourse. If the penis bends more than 60 degrees, couples usually are unable to have intercourse. Many men are extremely distressed by this curvature of their penis.


— There is currently only one US Food and Drug Administration (FDA)-approved treatment, known as collagenase (brand name: Xiaflex) injections. These injections are placed directly into the penile plaque, and they help remove the scar tissue. Studies have found that patients typically experience a 30 to 40 percent improvement in penile curvature after completing this type of therapy.

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